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DEA Annual Reports

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2020 2020 Report Cover Image

Use of Selumetinib to Treat Neurofibromatosis - - Neurofibromatosis type 1 (NF1) is a common genetic disorder (1:3,000) characterized by a variety of progressive manifestations including the development of tumors called plexiform neurofibromas (PNs), many of which occur in very young children.

2019 2019 Report Cover Image

Immunotoxins for Cancer Therapy - - With the U.S. Food and Drug Administration (FDA) approval of the immunotoxin moxetumomab pasudotox (Lumoxiti) for treatment of drug-resistant hairy cell leukemia (HCL)...

2018 2018 Report Cover Image

T-Cell Receptor Gene Therapy for Epithelial Cancer - - T-cell receptor (TCR) gene therapy is an emerging class of cancer treatment that is based on the infusion of autologous T cells genetically engineered to express a tumor antigen-targeting TCR.

2017 2017 Report Cover Image

The Therapeutic Challenge of Brain Metastases of Breast Cancer - - Brain or Central Nervous System (CNS) metastases of breast cancer have become more prevlent as systemic therapies improved. For breast cancer patients whose tumor overexpresses the HER2 oncogene, 37% of metastatic patients develop brain metastases, often when they are responding to therpay or have stable systemic disease.

2016 2016 Report Cover Image

The Highjacking of Topoisomerases by Anticancer Drugs - - Topoisomerases exist in all forms of life where long DNA and RNA polymers are susceptible to get tangled and need to be tightly packaged, accessible in interphase, and separated during mitosis.

2015 2015 Report Cover Image

The RAS Initiative - The RAS family of oncogenes were the first oncogenes identified in human cancer cell DNA in 1981. Activating mutations in RAS genes, in particular KRAS, are observed in about 35 percent of lung adenocarcinomas and more than 90 percent of pancreatic cancers.

2014 2014 Report Cover Image

Molecular Analysis for Therapy Choice (NCI-Match): A Novel Clinical Trial - The goal of NCI-MATCH is to provide clinical evidence that a drug targeting a particular molecular profile may also be effective in the treatment of more than one tumor type.

2013 2013 Report Cover Image

A Precision Medicine Research Strategy - To Integrate a Taxonomic Classification of Cancer and Translate it into the Clinic. The concept that developed, that of Precision Medicine, includes four basic premises; Information Commons, Knowledge Network, Taxonomic Classifiers, and Precision Medicine.

2012 2012 Report Cover Image

Molecular Diagnosis of Lymphoid Malignancies - Diffuse large B cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphona is iagnosed in more than 20,000 individuals per year in the United States.

2011 2011 Report Cover Image

Deciphering the Complexity of Drug Resistance in Cancer - Cellular and molecular approaches to the study of multidrug resistance in cancer.

2010 2010 Report Cover Image

Personalized Immunotherapy - Identify the Cancer Antigen and Create the Anti-Tumor T Cell

2009 2009 Report Cover Image

Glioblastoma-Derived Tumor Stem Cells - The generation of tumor stem cell-derived neurospheres from patient-derived glioblastoma tissue.

2008 2008 Report Cover Image

Interleukin-15 in the Life and Death of Lymphocytes: A Target for Cancer Therapy and Vaccine Design - The structure of IL-15; A model of IL-15 receptor alpha chain (IL-15Rα) presentation of IL-15 in trans to neighboring NK and CD8+ T cells.

2007 2007 Report Cover Image

Identifying Interleukin-7 As a Master Regulator of T Cell Homeostasis: Clinical Implications and New Therapeutic Opportunities - Protein Data Bank Model of IL-7 Engaging the IL7R on the surface of a T cell.

2006 2006 Report Cover Image

The Genetic Basis of Kidney Cancer Opportunities for Disease-Specific Targeted Therapy - The genes associated with the development of cancer of the kidney have in common their interaction with pathways that control oxygen and nutrient sensing.

2005 2005 Report Cover Image

A Vaccine to Prevent Cervical Cancer and Other Diseases Caused by HPV Infection - 1. Authentic bovine papillomavirus virions; 2. Bovine papillomavirus-like particles; 3. Human papillomavirus-like particles; 4. 3-D reconstruction of cryo-electron micrograph of authentic papillomavirus virion (blue) coated with neutralizing antibody (red).

2004 2004 Report Cover Image

Molecular Imaging for Cancer - Two different types of molecular imaging techniques applied to cancer detection: positron emission tomography-computed tomography (PET-CT) fusion imaging; magnetic resonance images (MRI) using a superparamagentic imaging agent [monocrystalline iron oxide nanoparticle (MION)]

2003 2003 Report Cover Image

Chemical Genetics and New Treatments for Cancer - Results of screening small molecules in the cytoblot assay for their ability to cause hyperacetylation of tubulin (left) and histone (right) proteins in lung epithelial cells.

2002 2002 Report Cover Image

Molecular Diagnosis of Cancer - Photomicrographs of lymph node biopsies from two patients with diffuse large B cell lymphoma.

2001 2001 Report Cover Image

Immunotoxin Therapy of Hairy Cell Leukemia With BL22

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