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Division of Extramural Activities
NCI Grant Activity Codes/Mechanisms & Descriptions
C06DP1DP5DP2DP43F31F32F33K01K05K07K08K12K18K22K23K24K25K99L30L32L40L50
L60P01P20P30P41P50R00R01R03R13R15R18R21R24R25R33R34R36R37R41R42R43R44
R55R56RC1RC2S06S15S21SC1SC2SI2TU2T15T32T34U01U10U13U19U24U42U43U44U54
U56UH2UM1X01X02
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C-06 Research Facilities Construction Grants
To provide matching Federal funds, up to 75 percent, for construction or major remodeling to create new research facilities. In addition to basic research laboratories, this may include, under certain circumstances, animal facilities and/or limited clinical facilities where they are an integral part of an overall research effort.
NIH Policy
DP-1 NIH Director's Pioneer Award (NDPA)
Request for Information (RFI) on the NIH Plan to Develop the Genetic Testing Registry
DP-2 NIH Director's New Innovator Awards
The DP2 NIH Director’s New Innovator Awards provide support to highly innovative research projects by new investigators in all areas of biomedical and behavioral research.
DP-5 NIH Director's Early Independence Award
This research grant program will encourage exceptionally creative scientists to bypass the typical post-doc research training period in order to move rapidly to research independence.
DP-43 International Training Grants in Epidemiology
The D43 International Training Grants in Epidemiology provide support to improve and expand epidemiologic research and the utilization of epidemiology in clinical trials and prevention research in foreign countries through support of training programs for foreign health professionals, technicians, and other health care workers.
F-31 Predoctoral Individual National Research Service Award (NRSA)
To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.).
F-31 Predoctoral Fellowship--Minority Students
F-31 Predoctoral Fellowship--Students with Disabilities
F-32 National Research Service Award for Individual Postdoctoral Fellows
To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas
Program Announcements
F-33 NIH National Research Service Awards for Senior Fellows
To provide opportunities for experienced scientists to make major changes in the direction of research careers, to broaden scientific background, to acquire new research capabilities, to enlarge command of an allied research field, or to take time from regular professional responsibilities for the purpose of increasing capabilities to engage in health-related research.
Program Announcements
K-01 Mentored Research Scientist Development Award
Mentored Research Scientist Development Awards (K01s) provide support and “protected time” for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence. Some Institutes/Centers use the K01 to support individuals who propose to train in a new field; for individuals who have had a hiatus in their research career; or to increase research workforce diversity. The NCI supports the Mentored Research Scientist Development Award to Support Diversity.
Program Announcements
K-05 Established Investigator Award in Cancer Prevention, Control, Behavioral, and Population Research
For the support of a research scientist qualified to pursue independent research which would extend the research program of the sponsoring institution, or to direct an essential part of this research program.
Program Announcements
K-07 Cancer Prevention, Control, Behavioral, and Population Sciences Career Development Award
To provide support for more junior candidates who are interested in developing academic and research expertise in a specific area or to support more senior individuals with acknowledged scientific expertise and leadership skills who are interested in improving the curricula and enhancing the research capacity within an academic institution.
Program Announcements   NCI Guidelines
K-08 Minorities in Clinical Oncology
To support the development of outstanding clinical research scientists. It provides specialized study for clinically trained professionals who are committed to a career in research and have the potential to develop into independent investigators.
Program Announcements   PAR-09-050
K-12 Institutional Clinical Oncology Research Career Development Award
To support newly trained clinicians appointed by an institution for development of independent research skills and experience in a fundamental science within the framework of an interdisciplinary research and development program.
Program Announcements   NCI Guidelines
K-18 Career Enhancement Award for Stem Cell Research
To encourage investigators to obtain the training and career development they need to appropriately use stem cells in their research.
Program Announcements
K-22 The NCI Transition Career Development Award
To support clinical and postdoctoral fellows and new faculty working in cancer prevention, control, and population science ready to transition to independent academic faculty positions and to create equal access to extramural career development opportunities to postdoctoral scientists in basic human cancer research working as Federal employees.
Program Announcements   NCI Guidelines
K-22 The NCI Transition Career Development Award to Promote Diversity
To support advanced postdoctoral and/or newly independent research scientists representative of groups that are underrepresented in biomedical, behavioral, clinical, and/or social sciences and provide "protected time" for recipients to develop and receive support for their initial cancer research program. In addition, this award can provide a two-year mentored experience in NCI intramural programs for interested individuals.
Program Announcements
K-23 Mentored Patient-Oriented Research Career Development Award
To provide support for the career development of investigators who have made a commitment of focus their research endeavors on patient-oriented research. This mechanism provides support for a 3 year minimum up to 5 year period of supervised study and research for clinically trained professionals who have the potential to develop into productive, clinical investigators.
Program Announcements   NCI Guidelines
K-23 Mentored Patient-Oriented Research Career Development Award to Promote Diversity
Program Announcements   PAR-09-051
K-24 Midcareer Investigator Award in Patient-Oriented Research
To provide support for clinicians to allow them protected time to devote to patient-oriented research and to act as mentors for beginning clinical investigators. The target candidates are outstanding clinical scientists engaged in patient-oriented research who are within 15 years of their specialty training, who can demonstrate the need for a period of intensive research focus as a means of enhancing their clinical research careers, and who are committed to mentoring the next generation of clinical investigators in patient-oriented research.
Program Announcements
K-25 Mentored Quantitative Research Career Development Award
To support the career development of investigators with non-biomedical quantitative and engineering backgrounds who have made a commitment to focus their research career on basic or clinical medical research.
Program Announcements
K-99/R-00 Howard Temin Pathway to Independence Award
The NIH Pathway to Independence Award provides an opportunity for promising postdoctoral scientists to receive both mentored and independent research support from the same award. The initial phase will provide 1-2 years of mentored support for highly promising, postdoctoral research scientists followed by up to 3 years of independent support contingent on securing an independent research position.
Program Announcements
L-30 Loan Repayment Program for Clinical Researchers
To provide for the repayment of the educational loan debt of qualified health professionals involved in clinical research. Qualified health professionals who contractually agree to conduct qualified clinical research are eligible to apply for this program.
NIH Guidelines
L-32 Loan Repayment Program for Clinical Researchers from Disadvantaged Backgrounds
To provide for the repayment of the educational loan debt of qualified health professionals from disadvantaged backgrounds involved in clinical research. Qualified health professionals from disadvantaged backgrounds who contractually agree to conduct qualified clinical research are eligible to apply for this program
NIH Guidelines
L-40 Loan Repayment Program for Pediatric Research
To provide for the repayment of the educational loan debt of qualified health professionals involved in research directly related to diseases, disorders, and other conditions in children. Qualified health professionals who contractually agree to conduct qualified pediatric research are eligible to apply for this program.
NIH Guidelines
L-50 Loan Repayment Program for Contraception and Infertility Research
To provide for the repayment of the educational loan debt of qualified health professionals (including graduate students) who contractually agree to commit to conduct qualified contraception and/or infertility research.
NIH Guidelines
L-60 Loan Repayment Program for Health Disparities Research (HD-LRP)
To provide for the repayment of the educational loan debt of qualified health professionals involved in minority health and health disparities research, for the purposes of improving minority health and reducing health disparities. Qualified health professionals who contractually agree to conduct qualified minority health disparities research or other health disparities research eligible to apply for this program.
NIH Guidelines
P-01 Research Program Projects
To support multidisciplinary or multifaceted research programs that have a focused theme. Each component project should be directly related to and contribute to the common theme.
Program Announcements    P-01 Guidelines [03/13]    Supplemental Material
P-20/P-30 Cancer Centers Programs & General Information
Cancer Centers Programs
P-20 Exploratory Grants
To support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to the development of interdisciplinary programs that offer potential solutions to problems of special significance to the mission of the NIH. These exploratory studies may lead to specialized or comprehensive centers.
Program Announcements    NCI Guidelines
P-30 Center Core Grants
To support shared use of resources and facilities for categorical research by investigators from different disciplines who provide a multidisciplinary approach to a joint research effort, or by investigators from the same discipline who focus on a common research problem. The core grant is integrated with the center's component projects or Program Projects, though funded independently from them. This support, by providing more accessible resources, is expected to assure greater productivity than that provided through the separate projects and Program Projects.
Program Announcements    Cancer Center Program
Scientific Information for Centers and Researchers
P-41 Biotechnology Resource Grant Program
P-50 Specialized Center Grants
To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R & D effort. The spectrum of activities comprise a multidisciplinary attack on a specific disease entity or biomedical problem area. There grants differ from program project grants in that they are usually developed in response to an announcement of the programmatic needs to an Institute or Division and subsequently receive continuous attention from staff. Centers may also serve as regional or national resources for special research purposes.
Program Announcements    SPORE Guidelines
Translational Research Program (TRP) is the home of the Specialized Programs of Research Excellence (SPOREs)
R-01 Research Project
Grants are awarded to institutions to allow a Principal Investigator to pursue a scientific focus or objective in his or her area of interest and competence. Institutional sponsorship assures the NIH that the institution will provide facilities necessary to conduct the research and will be accountable for the grant funds. Applications are accepted for health-related research and development in all areas within the scope of the NIH's mission.
Program Announcements
R-03 Small Research Grants
Small grants provide research support, specifically limited in time and amount, for activities such as pilot projects, testing of new techniques, or feasibility studies of innovative, high-risk research, which would provide a basis for more extended research.
Program Announcements    NIH Guidelines
R-13 Conference Grants
NCI assists in funding conferences relevant to its mission. Generally, such awards are limited to participation with other organizations in supporting conferences rather than providing sole support. Prospective applicants are urged to initiate contact no later than 6 weeks before submission of their application. The conference must occur more than 6 months after the receipt date deadline, in order for the application and its review to be considered by the NCI's council and possibly awarded if sufficiently meritorious. A sufficiently meritorious R13 application can only be awarded after completion of the appropriate meeting of the NCI’s council (i.e., the one at which it and its associated summary statement from peer review are presented) and before the start of the conference for which funding is requested.
Program Announcements    NIH Guidelines    NCI Support Contacts
R-15 The NIH Academic Research Enhancement Awards (AREA)
To enhance the research environment of educational institutions that have not been traditional recipients of NIH research funds, this award provides limited funds to those institutions' faculty members to develop new research projects or expand ongoing research activities in health sciences and to encourage students to participate in the research activity. As funds are anticipated to continue to be available each year, the NIH is now inviting applications for AREA grants through a standing, ongoing Program Announcement.
Program Announcements    NIH Guidelines
R-18 Research Demonstration and Dissemination Projects
To provide support designed to develop, test, and evaluate health service activities, and to foster the application of existing knowledge for the control of categorical diseases.
R-21 Exploratory/Developmental Grants
To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and duration.).
Program Announcements    NIH Guidelines
R-24 Resource-Related Research Projects
To support research projects that will enhance the capability of resources to serve biomedical research.
Program Announcements
R-25 Cancer Education Projects
To support the development and implementation of programs related to education, information provision, training, technical assistance, coordination, or evaluation.
Program Announcements
R-25E Cancer Education Grant Program
To provide funding for the development of: 1) innovative cancer education programs; and 2) cancer research dissemination projects that can be completed within 5 years.
Program Announcements
R-25T Cancer Education and Career Development Program
To support development and/or implementation of a program related to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation.
Program Announcements    NCI Guidelines    PAR-10-165
Supplements to R25T Guidelines [11/01]
R-33 Exploratory/Developmental Grants Phase II
To provide a second phase for support of innovative exploratory and developmental research activities initiated under the R21 mechanism. Although only R21 awardees are generally eligible to apply for R33 support, specific program initiatives may establish eligibility criteria under which applications could be accepted from applicants who demonstrate program competency equivalent to that expected under R33.
Program Announcements
R-34 Clinical Trial Planning Grant
To provide support for the initial development of a clinical trial, including the establishment of the research team; the development of tools for data management and oversight of the research; and, the development of a trial design and other essential elements of the study, such as the protocol, recruitment strategies, and procedure manuals.
R-36 Dissertation Award
To support dissertation research costs of students in accredited research doctoral programs in the United States (including Puerto Rico and other U.S. territories or possessions). Dissertation awards are not renewable.
R-37 Method to Extend Research in Time (MERIT) Award
To provide long-term grant support to investigators whose research competence and productivity are distinctly superior and who are highly likely to continue to perform in an outstanding manner. Investigators may not apply for a MERIT award. Program staff and/or members of the cognizant National Advisory Council/Board will identify candidates for the MERIT award during the course of review of competing research grant applications prepared and submitted in accordance with regular PHS requirements.
Small Business Innovation Research (SBIR) and
Small Business Technology Transfer (STTR) Programs

The NIH welcomes grant applications from small businesses in any biomedical or behavioral research area as described in the solicitations below. Support under the SBIR program is normally provided for 6 months/$100,000 for Phase I, and 2 years/$500,000 for Phase II. However, applicants may propose longer periods of time and greater amounts of funds necessary for completion of the project.
R-41 Small Business Technology Transfer (STTR) Grants - Phase I
To support cooperative R&D projects between small business concerns and research institutions, limited in time and amount, to establish the technical merit and feasibility of ideas that have potential for commercialization.
Program Announcements    NCI Resource Center
Advice and Information on SBIR/STTR Programs
R-42 Small Business Technology Transfer (STTR) Grants - Phase II
To support in-depth development of cooperative R&D projects between small business concerns and research institutions, limited in time and amount, whose feasibility has been established in Phase I and that have potential for commercial product(s) or service(s).
Program Announcements    NCI Resource Center
Advice and Information on SBIR/STTR Programs
R-43 Small Business Innovation Research Grants (SBIR) - Phase I
To support projects, limited in time and amount, to establish the technical merit and feasibility of R&D ideas that may ultimately lead to commercial products or services.
Program Announcements    NCI Resource Center
Advice and Information on SBIR/STTR Programs
R-44 Small Business Innovation Research Grants (SBIR) - Phase II
To support in-depth development of R&D ideas whose feasibility have been established in Phase I that are likely to result in commercial products or services.
Program Announcements    NCI Resource Center
Advice and Information on SBIR/STTR Programs
R-55 James A. Shannon Director's Award
To provide a limited award to investigators to further develop, test, and refine research techniques; perform secondary analysis of available data sets; test the feasibility of innovative and creative approaches; and conduct other discrete projects that can demonstrate their research capabilities and lend additional weight to their already meritorious applications.
R-56 High Priority, Short-Term Project Award
To provide limited interim research support based on the merit of a pending R01 application while applicant gathers additional data to revise a new or competing renewal application. Applicants do not submit requests for a High Priority Award (R56). Instead, NCI program staff nominate previously reviewed R01 applications that are beyond the current NCI payline but, because of their merit, are eligible for funding.
RC-1 NIH Challenge Grants and Partnerships Program
NIH Challenge Grants in Health and Science Research.
NIH Guidelines
RC-2 High Impact Research and Research Infrastructure Programs
To support high impact ideas that may lay the foundation for new fields of investigation; accelerate breakthroughs; stimulate early and applied research on cutting-edge technologies; foster new approaches to improve the interactions among multi- and interdisciplinary research teams; or, advance the research enterprise in a way that could stimulate future growth and investments and advance public health and health care delivery.
S-06 Minority Biomedical Research Support (MBRS)
To strengthen the biomedical research and research training capability of ethnic minority institutions, and thus establish a more favorable milieu for increasing the involvement of minority faculty and students in biomedical research.
S-15 Small Instrumentation Grants Program
S-21 Research and Institutional Resources Health Disparities Endowment Grants - Capacity Building
To strengthen the research and training infrastructure of the institution, while addressing current and emerging needs in minority health and other health disparities research.
SC-1 Research Enhancement Award
The SC1 Research Enhancement Awards provide support for individual investigator-initiated research projects aimed at developing researchers at minority-serving institutions (MSIs) to a stage where they can transition successfully to others extramural support (R01 or equivalent).
SC-2 Pilot Research Project
The SC2 Pilot Research Project grants provide support for individual investigator-initiated pilot research projects for faculty at MSIs to generate preliminary data for a more ambitious research project.
SI-2 Intramural Clinical Scholar Research Award
This program will encourage exceptionally talented clinical researchers to conduct research in the Intramural Research Program for a specified period of time who will then be able to work with an extramural institution to develop an independent research grant application for follow-on support.
TU-2 Institutional National Research Service Award with Involvement of NIH Intramural Faculty
The cooperative agreement counterpart to the T32, this award enables institutions to provide research-training experiences for graduate students and postdoctoral scientists in specified shortage areas. In addition, these awards involve identified NIH Intramural Staff who serve as a part of the training faculty and participate in the operation of the training program.
T-15 Continuing Education Training Program
Program Announcements
T-32 NIH National Research Service Award - Institutional Research Training Grants
To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas.
Program Announcements    NCI Supplemental Policy
Supplemental Guidelines [03/02]
T-34 MARC Undergraduate NRSA Institutional Grants
To enable minority institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in the biomedical and behavioral sciences.
U-01 Research Project
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his specific interest and competencies
Program Announcements
U-10 Cooperative Clinical Research--Cooperative Agreements
To support clinical evaluation of various methods of therapy and/or prevention in specific disease areas. These represent cooperative programs between sponsoring institutions and participating principal investigators, and are usually conducted under established protocols.
Program Announcements
U-13 Conference--Cooperative Agreements
U-19 Research Program--Cooperative Agreements
To support a research program of multiple projects directed toward a specific major objective, basic theme or program goal, requiring a broadly based, multidisciplinary and often long-term approach.
U-24 Resource-Related Research Projects--Cooperative Agreements
To support research projects contributing to improvement of the capability of resources to serve biomedical research.
U-42 Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials (NCRR)
U-43 Small Business Innovative Research Grant (SBIR/Phase I)
U-44 Small Business Innovative Research Grant (SBIR/Phase II)
U-54 Specialized Center-Cooperative Agreements
To support any part of the full range of research and development from very basic to clinical; may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. The spectrum of activities comprises a multidisciplinary attack on a specific disease entity or biomedical problem area. These differ from program project in that they are usually developed in response to an announcement of the programmatic needs of an Institute or Division and subsequently receive continuous attention from its staff. Centers may also serve as regional or national resources for special research purposes, with funding component staff helping to identify appropriate priority needs.
U-56 Exploratory Grants--Cooperative Agreements
To support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to the development of interdisciplinary programs that offer potential solutions to problems of special significance to the mission of the NIH. These exploratory studies may lead to specialized or comprehensive centers. Substantial Federal programmatic staff involvement is intended to assist investigators during performance of the research activities, as defined in the terms and conditions of award.
U-56 Exploratory Grants--Cooperative Agreements
To support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to the development of interdisciplinary programs that offer potential solutions to problems of special significance to the mission of the NIH. These exploratory studies may lead to specialized or comprehensive centers. Substantial Federal programmatic staff involvement is intended to assist investigators during performance of the research activities, as defined in the terms and conditions of award.
UH-2 Exploratory/Developmental Cooperative Agreement Phase I
To support the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.)
UM-1 Multi-component Research Project Cooperative Agreement
To support large-scale cooperative agreements involving complex clinical trials with multiple components, e.g. clinical networks. The components represent a variety of supporting functions and are not independent of research projects.
X-01 Resource Access Award
To invite investigators to apply for access to government funded resources, such as the NIH Rapid Access to Interventional Development (RAID) Program and the High Throughput Genotyping Resource.
X-02 Preapplication
In cooperation with public and private nonprofit organizations, for-profit organizations and Federal laboratories, to invite investigators to submit preapplications for those funding opportunities that employ a preapplication as a part of the peer review process.